Association of MAOA-uVNTR gene polymorphism with hostility in male population aged of 45-64 in Russia / Siberia: International Programs: WHO MONICA-psychosocial, HAPIEE
Objective: to study the association of hostility with high and low-active variants of the MAOA gene in an open population of men 45-64 years old.
Methods: Under the WHO International Program “MONICA-psychosocial” and “HAPIEE”, a representative sample of men aged 45–64 years old (n = 781 men, average age was 56.48 ± 0.2 years) in 2003-2005. All respondents self-completed a questionnaire on hostility. Using the random number method 156 men were selected who were genotyped for MAOA-uVNTR polymorphism from the surveyed sample.
Results: It was found the level of hostility in the population of men was 60.3%. It was revealed that in persons with low-active alleles of the MAOA-L gene (allele 2 and 3) a high level of hostility was more common – 50.9%. The results of a logistic regression model showed that the presence of low-active alleles (2; 3) of the MAOA gene increases the likelihood of hostility OR = 2,103 (95% CI 1,137-3,889, p = 0.018).
Conclusions: Our findings suggest that the low-active allele of the MAOA-L gene is associated with hostility.
Key words: MAOA gene, hostility, population, men
Gafarov, V.V. 1,2, Gromova, E.A. 1,2, Panov, D.O. 1,2, Gagulin, I.V. 1,2, Gafarova, A.V. 1,2, Maksimov, V.N. 1
1 Institute of Internal and Preventive Medicine – branch of Institute of Cytology and Genetics SB RAS, B. Bogatkov st. 175/1, 630089, Novosibirsk, Russian Federation
2 Collaborative laboratory of Cardiovascular Diseases Epidemiology, B. Bogatkov st. 175/1, 630089, Novosibirsk, Russian Federation